Welcome to the Wealth of the Rainforest
    Pharmacy to the World

Menu

Products

Graviola Max Capsules


This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information on why. Click on one of the product search links in the left margin of this page to find other available products. You can also see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants in general.

Some of the active ingredients documented, researched, and verified in graviola are a group of Annonaceous acetogenins which are only found in the Annonaceae plant family. Graviola (Annona muricata) has 82 different acetogenin chemicals (in 10 distinct types). Mountain graviola (Annona montana) contains the main annonacin chemical that graviola does, and, it has 26 more acetogenin chemicals not found in graviola (in 6 distinct types)! Graviola Max combines both species of graviola (Annona muricata and Annona montana) to provide 12 different types of acetogenins—108 distinct powerful chemicals in all. Compare that to only 28 acetogenin chemicals found in the American paw paw. . . Graviola Max delivers almost four times more acetogenins than paw paw!

For more complete information on this powerful plant of the rainforest, please see the plant database file on graviola. More information on Graviola Max can be found the in the new Anti-Cancerous Guide

Graviola was featured in three articles by The Health Sciences Institute which are accessible here:

  • HSI Article 1

  • HSI Article 2

  • HSI Article 3

     Traditional Uses:* for cancer (all types); as a broad-spectrum internal and external antimicrobial to treat bacterial and fungal infections; for internal parasites and worms; for high blood pressure; for depression, stress, and nervous disorders

    Ingredients: A blend of graviola leaf and stem (Annona muricata), and mountain graviola leaf and stem (Annona montana).
    Suggested Use: Take 3 capsules 3-4 times or as directed by a healthcare professional.
    Contraindications:
    • 1. Not to be used during pregnancy or breast-feeding.
    • 2. Graviola has demonstrated hypotensive, vasodilator, and cardiodepressant activities in animal studies. People with low blood pressure should monitor their blood pressure accordingly.
    • 3. Graviola has recently been documented to lower blood sugar in animal studies. People with hypoglycemia and diabetes should monitor their blood sugar levels accordingly.
    Drug Interactions: None have been reported; however, based on animal studies, graviola may enhance the effect of high blood pressure drugs and diabetes drugs.

    Other Practitioner Observations:
    • 1. Graviola has demonstrated in vitro antimicrobial properties. Chronic, long-term use of this plant might lead to some die-off of friendly bacteria in the digestive tract. Supplementing the diet with probiotics and digestive enzymes may be helpful to counteract this possible effect.
    • 2. Graviola has demonstrated emetic properties in one animal study with pigs. Large single dosages may cause nausea or vomiting. Reduce the usage accordingly or take with a meal if nausea occurs.
    • 3. Drinking plenty of water (at least 8 glasses a day) is helpful to reduce Herxheimer reactions and flush dead and dying cells from the body.
    • 4. One of three documented mechanisms of action of graviola is by decreasing energy to abnormal cells (called an ATP-inhibitor). Taking supplements that increase cellular energy (like CoQ10) will counteract or disable this one mechanism of action of graviola (however, the other two mechanisms of action will be unaffected).


    Third-Party Published Research on Graviola


    All available third-party documentation and research on graviola be found at PubMed. A partial listing of the third-party published research on graviola is shown below:


    Anticancerous & Antitumor Actions:
    Torres, M., et al. "Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism." Cancer Lett. 2012 Oct 1;323(1):29-40.
    de Pedro N, et al. "Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I." J Bioenerg Biomembr. 2012 Nov 21. [Epub ahead of print]
    de Pedro N, et al. "Mitochondrial complex I inhibitors, acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway." J Bioenerg Biomembr. 2012 Nov 21. [Epub ahead of print]
    Hamizah, S., et al. "Chemopreventive potential of Annona muricata L leaves on chemically-induced skin papillomagenesis in mice." Asian Pac J Cancer Prev. 2012;13(6):2533-9.
    Chen, Y., et al. "Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds." J Ethnopharmacol. 2012 Jul 13;142(2):462-6.
    Chen, Y., et al. "Antitumor activity of annonaceous acetogenins in HepS and S180 xenografts bearing mice." Bioorg Med Chem Lett. 2012 Apr 15;22(8):2717-9.
    George, V., et al. "Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines." Asian Pac J Cancer Prev. 2012;13(2):699-704.
    Gomes de Melo, J., et al. "Antiproliferative activity, antioxidant capacity and tannin content in plants of semi-arid northeastern Brazil." Molecules. 2010 Nov 24;15(12):8534-42.
    Ko, Y., et al. "Annonacin induces cell cycle-dependent growth arrest and apoptosis in estrogen receptor-?-related pathways in MCF-7 cells." J Ethnopharmacol. 2011 Oct 11;137(3):1283-90.
    Tantithanaporn, S., et al. "Cytotoxic activity of acetogenins and styryl lactones isolated from Goniothalamus undulatus Ridl. root extracts against a lung cancer cell line (COR-L23)." Phytomedicine. 2011 Apr 15;18(6):486-90.
    Coothankandaswamy, V., et al. "The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway." J Nat Prod. 2010 May 28;73(5):956-61.
    Yang, h., et al. "Structure-activity relationships of diverse annonaceous acetogenins against human tumor cells." Bioorg Med Chem Lett. 2009 Apr 15;19(8):2199-202.
    Kojima, N. "Systematic synthesis of antitumor Annonaceous acetogenins" Yakugaku Zasshi. 2004; 124(10): 673-81.
    Tormo, J. R., et al. "In vitro antitumor structure-activity relationships of threo/trans/threo mono-tetrahydro-furanic acetogenins: Correlations with their inhibition of mitochondrial complex I." Oncol. Res. 2003; 14(3): 147-54.
    Yuan, S. S., et al. "Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway." Life Sci. 2003 May: 72(25): 2853-61.
    Liaw, C. C., et al. "New cytotoxic monotetrahydrofuran Annonaceous acetogenins from Annona muricata." J. Nat. Prod. 2002; 65(4): 470-75
    Gonzalez-Coloma, A., et al. "Selective action of acetogenin mitochondrial complex I inhibitors." Z. Naturforsch. 2002; 57(11-12): 1028-34.
    Chang, F. R., et al. "Novel cytotoxic Annonaceous acetogenins from Annona muricata." J. Nat. Prod. 2001; 64(7): 925-31.
    Jaramillo, M. C., et al. "Cytotoxicity and antileishmanial activity of Annona muricata pericarp." Fitoterapia. 2000; 71 (2): 183-6.
    Betancur-Galvis, L., et al. "Antitumor and antiviral activity of Colombian medicinal plant extracts." Mem. Inst. Oswaldo Cruz. 1999; 94(4): 531-35.
    Kim, G. S., et al. "Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata." Phytochemistry. 1998; 49(2): 565-71.
    Kim, G. S., et al. "Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata." J. Nat. Prod. 1998; 61(4): 432-36.
    Nicolas, H., et al. "Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells." J. Med. Chem. 1997; 40(13): 2102-6.
    Zeng, L., et al. "Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata." J. Nat. Prod. 1996; 59(11): 1035-42.
    Wu, F. E., et al. "Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata." J. Nat. Prod. 1995; 58(6): 830-36.
    Oberlies, N. H., et al. "Tumor cell growth inhibition by several Annonaceous acetogenins in an in vitro disk diffusion assay." Cancer Lett. 1995; 96(1): 55-62.
    Wu, F. E., et al. "Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata." J. Nat. Prod. 1995; 58(9): 1430-37.
    Wu, F. E., et al. "New bioactive monotetrahydrofuran Annonaceous acetogenins, annomuricin C and muricatocin C, from the leaves of Annona muricata." J. Nat. Prod. 1995; 58(6): 909-5.
    Wu, F. E., et al. "Muricatocins A and B, two new bioactive monotetrahydrofuran Annonaceous acetogenins from the leaves of Annona muricata." J. Nat. Prod. 1995; 58(6): 902-8.
    Sundarrao, K., et al. "Preliminary screening of antibacterial and antitumor activities of Papua New Guinean native medicinal plants." Int. J. Pharmacog. 1993; 31(1): 3-6.

    Antimicrobial Actions:
    Feng, L., et al. "Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniae." Bioorg Med Chem. 2011 Jun 1;19(11):3512-9.
    Viera, G., et al. "Antibacterial effect (in vitro) of Moringa oleifera and Annona muricata against Gram positive and Gram negative bacteria." Rev Inst Med Trop Sao Paulo. 2010 May-Jun;52(3):129-32.
    Takahashi, J.A., et al. "Antibacterial activity of eight Brazilian Annonaceae plants." Nat. Prod. Res. 2006; 20(1): 21-6.
    Betancur-Galvis, L., et al. "Antitumor and antiviral activity of Colombian medicinal plant extracts." Mem. Inst. Oswaldo Cruz 1999; 94(4): 531-35.
    Antoun, M. D., et al. "Evaluation of the flora of Puerto Rico for in vitro cytotoxic and anti-HIV activities." Pharmaceutical Biol. 1999; 37(4): 277-280.
    Padma, P., et al. "Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus." J. Ethnopharmacol. 1998; 61(1): 81-3.
    Sundarrao, K., et al. "Preliminary screening of antibacterial and antitumor activities of Papua New Guinean native medicinal plants." Int. J. Pharmacog. 1993; 31(1): 3-6.
    Misas, C. A. J., et al. "Contribution to the biological evaluation of Cuban plants. IV." Rev. Cubana Med. Trop. 1979; 31(1): 29-35.

    Antidepressant & Antistress Actions:
    Padma, P., et al. "Effect of Annona muricata and Polyalthia cerasoides on brain neurotransmitters and enzyme monoamine oxidase following cold immobilization stress." J. Natural Remedies 2001; 1(2): 144-46.
    Hasrat, J. A., et al. "Screening of medicinal plants from Suriname for 5-HT 1A ligands: Bioactive isoquinoline alkaloids from the fruit of Annona muricata." Phytomedicine. 1997; 4(20: 133-140.
    Padma, P., et al. "Effect of alcohol extract of Annona muricata on cold immobilization stress induced tissue lipid peroxidation." Phytother. Res. 1997; 11(4): 326-327.
    Hasrat, J. A., et al. "Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats: unexploited antidepressive (lead) products." J. Pharm. Pharmacol. 1997; 49(11): 1145-49.

    Antiparasitic, Antimalarial, & Insecticidal Actions:
    Grzybowski, A., et al. "Synergistic larvicidal effect and morphological alterations induced by ethanolic extracts of Annona muricata and Piper nigrum against the dengue fever vector Aedes aegypti." Pest Manag Sci. 2012 Sep 19. doi: 10.1002/ps.3409. [Epub ahead of print]
    Vila-Nova N., et al. "Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil." Rev Soc Bras Med Trop. 2011 Oct;44(5):567-71.
    Broglio-Micheletti S., et al. "[Plant extracts in control of Rhipicephalus (Boophilus) microplus (Canestrini, 1887) (Acari: Ixodidae) in laboratory]." Rev Bras Parasitol Vet. 2009 Oct-Dec;18(4):44-8.
    Osorio, E., et al. "Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae." J Ethnopharmacol. 2007 May 22;111(3):630-5.
    Luna, J. S., et al. "Acetogenins in Annona muricata L. (Annonaceae) leaves are potent molluscicides." Nat. Prod. Res. 2006; 20(3): 253-7.
    Jaramillo, M. C., et al. "Cytotoxicity and antileishmanial activity of Annona muricata pericarp." Fitoterapia. 2000; 71(2): 183-6.
    Alali, F. Q., et al. "Annonaceous acetogenins as natural pesticides; potent toxicity against insecticide-susceptible and resistant German cockroaches (Dictyoptera: Blattellidae)." J. Econ. Entomol. 1998; 91(3): 641-9.
    Antoun, M. D., et al. "Screening of the flora of Puerto Rico for potential antimalarial bioactives." Int. J. Pharmacog. 1993; 31(4): 255-58.
    Heinrich, M., et al. "Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico)." J. Ethnopharmacol. 1992; 36(1): 81-5.
    Bories, C., et al. "Antiparasitic activity of Annona muricata and Annona cherimolia seeds." Planta Med. 1991; 57(5): 434-36.
    Gbeassor, M., et al. "In vitro antimalarial activity of six medicinal plants." Phytother. Res. 1990; 4(3): 115-17.
    Tattersfield, F., et al. "The insecticidal properties of certain species of Annona and an Indian strain of Mundulea sericea (Supli)." Ann. Appl. Biol. 1940; 27: 262-73.

    Anti-Diabetes Action:
    Adeyemi, D., et al. "Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with extracts of Annona muricata." Folia Morphol (Warsz). 2010 May;69(2):92-100.
    Adeyemi, D., et al. "Anti hyperglycemic activities of Annona muricata (Linn)" Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):62-9.
    Adewole, S., et al. "Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats." Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):30-41.

    Anticonvulsant, Antispasmodic, & Smooth Muscle Relaxant Actions:
    N’gouemo, P., et al. "Effects of ethanol extract of Annona muricata on pentylenetetrazol-induced convulsive seizures in mice." Phytother. Res. 1997; 11(3): 243-45.
    Feng, P. C., et al. "Pharmacological screening of some West Indian medicinal plants." J. Pharm. Pharmacol. 1962; 14: 556-61.

    Hypotensive & Cardiodepressant Actions
    Nwokocha, C., et al. "Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague-Dawley rats." Pharm Biol. 2012 Nov;50(11):1436-41.
    Carbajal, D., et al. "Pharmacological screening of plant decoctions commonly used in Cuban folk medicine." J. Ethnopharmacol. 1991; 33(1/2): 21-4.
    Feng, P. C., et al. "Pharmacological screening of some West Indian medicinal plants." J. Pharm. Pharmacol. 1962; 14: 556-61.
    Meyer, T. M. "The alkaloids of Annona muricata." Ing. Ned. Indie. 1941; 8(6): 64.

    Pain-Relieving & Anti-inflammatory Actions:
    de Sousa, O., et al. "Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models." Int J Mol Sci. 2010 May 6;11(5):2067-78

    Antioxidant Actions:
    Nawwar, M., et al. "A flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of Annona muricata Linn." Arch Pharm Res. 2012 May;35(5):761-7.
    Adewole, S., et al. "Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats." Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):30-41.
    Baskar, R., et al. "In vitro antioxidant studies in leaves of Annona species." Indian J Exp Biol. 2007 May;45(5):480-5.

    • This is an informational site only and no products are sold. The statements contained herein have not been evaluated by the Food and Drug Administration. The information contained herein is intended for education, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. Please refer to our Conditions of Use or using this plant database file and web site.