Agricultural Research Service - ARS

Dr. Duke's
Phytochemical and Ethnobotanical Databases

Chemicals and their Biological Activities in: Uncaria tomentosa DC (Pedaliaceae) -- Cat's Claw, Garabato Amarillo, Una de Gato

Chemicals

3BETA,6BETA,19ALPHA-TRIHYDROXY-URS-12-EN-28-OIC-ACID Plant: JNP54:453
No activity reported.

5ALPHA-CARBOXYSTRICTOSIDINE Plant: JNP54:453
No activity reported.

ALLOISOPTEROPODINE Root: PAT.4,844,901
Immunostimulant RT.PAT.4,844,901

ALLOPTEROPODINE Root: PAT.4,844,901
Immunostimulant RT.PAT.4,844,901

ANGUSTINE Leaf: JNP41:503
Toxic JBH

DIHYDROCORYNANTHEINE Leaf: JNP41:503
Adrenergic-Blocker CPB38:1702 ; Antihypertensive JE36:219 ; Hypotensive PMP24:116

DIHYDROCORYNANTHEINE-N-OXIDE Leaf: JNP41:503
No activity reported.

HIRSUTEINE Leaf: JNP41:503
No activity reported.

HIRSUTINE Leaf: JNP41:503
Antihypertensive LS50:491 ; Calcium-Antagonist 1 uM; Myocontractant LS50:491

HIRSUTINE-N-OXIDE Leaf: JNP41:503
No activity reported.

ISOMITRAPHYLLINE Root 12.9 ppm; JAD
Phagocytotic DUKE1992B

ISOPTEROPODINE Root 19.3 ppm; JAD PAT.4,844,901
Phagocytotic DUKE1992B

ISORHYNCHOPHYLLINE Leaf: JNP41:503 Root 45.5 ppm; JAD PAT.4,844,901
Calcium-Antagonist 10.1 uM rat; Phagocytotic DUKE1992B

ISORHYNCHOPHYLLINE-N-OXIDE Leaf: JNP41:503
No activity reported.

ISOROTUNDIFOLINE Stem: JNP41:503
No activity reported.

MITRAPHYLLINE Bark: PM59:A583 PAT.4,844,901 Leaf: JNP41:503 Root 6.7 ppm; JAD
Hypotensive DUKE1992B ; Myorelaxant DUKE1992B ; Vasodilator DUKE1992B

OLEANOLIC-ACID Plant: JNP54:453
Abortifacient DUKE1992B ; Antiallergic LAF351 ; Antiatherosclerotic LAF351 ; Antibacterial MIC=625-1,250 ug/ml JNP59:987 ; Anticariogenic LAF ; Anticomplement IC40-50 0.01 mM/l gpg HH2 IC80-90 0.05 mM/l gpg HH2 ; Antiedemic IC36=40 mg/kg ipr rat DFN:159 ; Antifertility PMP24:113 ; Antigingivitic MIC=625-1,250 ug/ml JNP59:987 ; Antihepatotoxic PM56(2):173 ; AntiHIV EC50=1.7 ug/ml JNP61:1090 IC50=21.8 ug/ml; Antihyperlipidemic JE49:57 ; Antiinflammatory 40 mg/kg ipr JNP54:455 ; Antimalarial IC50=70-89 ug/ml PR13:115 ; Antioxidant BCI28:735 ; Antiperiodontic MIC=625-1,250 ug/ml JNP59:987 ; Antiplaque JNP59:987 ; Antiplasmodial IC50=70-89 ug/ml PR13:115 ; Antisarcomic DUKE1992B ; Antiseptic MIC=625-1,250 ug/ml JNP59:987 ; Antitumor LAF351 ; Antiulcer >carbenoxolone PJB1(1):181 ; Antiviral EC50=1.7 ug/ml JNP61:1090 IC50=21.8 ug/ml JNP61:1090 ; Aromatase-Inhibitor FIT68:387 ; Beta-Glucuronidase-Inhibitor ~100 mg/kg BO2 ; Cancer-Preventive 525 ; Cardiotonic LAF ; COX-2-Inhibitor IC50=295 uM/; Cyclooxygenase-Inhibitor DUKE1992B ; Diuretic LAF ; Elastase-Inhibitor IC50=~15 uM BO2 ; Hepatoprotective ACM:211 ; Hypolipemic LAF351 ; Immunomodulator LAF351 ; Phagocytotic LAF351 ; Piscicide WOI ; Prostaglandin-Synthesis-Inhibitor igs mus; Sedative LAF351 ; Uterotonic

PTEROPODINE Bark: PM59:A583 Root 3.2 ppm; JAD
Phagocytotic DUKE1992B

QUINOVIC-ACID-3BETA-O-(BETA-D-GLUCOPYRANOSYL-(1->3)BETA-D-FUCOPYRANOSYL-(27->1)BETA-D-GLUCOPYRANOSYL-ESTER Bark: PC30:1635
No activity reported.

QUINOVIC-ACID-3BETA-O-BETA-D-FUCOPYRANOSIDE Bark: PC30:1635
No activity reported.

QUINOVIC-ACID-3BETA-O-BETA-D-FUCOPYRANOSYL-(27->1)BETA-D-GLUCOPYRANOSYLESTER Bark: PC30:1635
No activity reported.

QUINOVIC-ACID-3BETA-O-BETA-D-QUINOVOPYRANOSIDE Bark: PC30:1635
No activity reported.

RHYNCHOPHYLLINE Leaf: JNP41:503 Root 23.3 ppm; JAD PAT.4,844,901
Calcium-Antagonist 10.1 uM rat M18481 ; Hypotensive DUKE1992B ; Neuroparalytic DUKE1992B ; Sedative DUKE1992B

RHYNCHOPHYLLINE-N-OXIDE Leaf: JNP41:503
No activity reported.

ROTUNDIFOLINE Stem: JNP41:503
No activity reported.

SPECIOPHYLLINE Bark: PM59:A583
No activity reported.

UNCARINE Bark: PM59:A583
No activity reported.

UNCARINE-F Plant: CAB
No activity reported.

URSOLIC-ACID Plant: JNP54:453
Analgesic FT63(3):195 ; Antialzheimeran JNP61:1212 ; Antiarthritic PM57:A56 ; Anticancer JNP61:1212 ; Anticancer (Colon) JNP61:1212 ; Anticariogenic LAF ; Anticholestatic 28-100 mg/kg orl PR6:74 ; Anticomplement IC100 0.1 mM/l gpg HH2 IC80-90 0.05 mM/l gpg HH2 ; Antidiabetic CCO ; AntiEBV CAN ; Antiedemic; Antifibrosarcomic IC80=10 uM BO2 ; Antihepatotoxic 5-20 mg/kg ipr PR6:74 ; Antihistaminic CPB39:3276 ; AntiHIV EC50=2.0 ug/ml JNP61:1090 IC50=6.5 ug/ml JNP61:1090 IC85=18 ug/ml JNP59:643 ; Antihyperlipidemic JE49:57 ; Antiinflammatory 1/3 indomethacin IC24=500 mg/kg; Antileishmanic ED50=20 uM POP:113 ; Antileukemic JNP53(3):513 ; Antilymphomic CAN ; Antimalarial IC50=28-37 ug/ml PR13:115 ; Antimetastatic IC80=10 uM BO2 ; Antimutagenic PPB17:990 ; Antiobesity? IJO16:4 ; Antioxidant BCI28:735 ; Antiplasmodial IC50=28-37 ug/ml PR13:115 ; Antiproliferative IC50=15-20 uM FT66(4):369 ; Antistaphylococcic CAN ; Antitumor CR54:701 ; Antitumor (Breast) 0.5% diet CLE104:43 IC50=15-20 uM FT66(4):369 ; Antitumor (Colon) CAN ; Antitumor (Lung) CAN ; Antitumor (Stomach) FT66(4):369 ; Antitumor-Promoter PM57:A56 ; Antiulcer PR6:74 ; Antiviral IC85=18 ug/ml; Aromatase-Inhibitor FIT68:387 ; Beta-Glucuronidase-Inhibitor ~100 mg/kg BO2 ; Cancer-Preventive 525 ; Choleretic 5-20 mg/kg orl PR6:74 ; CNS-Depressant DUKE1992B ; COX-2-Inhibitor IC50=130 uM/; Cyclooxygenase-Inhibitor JNP61:1212 ; Cytotoxic 50 ppm JNP53(3):513 ED50=3.75 ug/ml JNP53(3):513 ; Diuretic DUKE1992B ; Elastase-Inhibitor IC50=~15 uM BO2 ; Hepatoprotective 1-100 ug/ml; Hypoglycemic JE27:243 ; Lipoxygenase-Inhibitor IC50=0.18 mM FT66(4):369 ; MMP-9-Inhibitor IC80=10 uM BO2 ; Ornithine-Decarboxylase-Inhibitor BO2 ; Pesticide DUKE1992B ; Piscicide DUKE1992B ; Potassium-Sparing 3 mg/rat IWU ; Protease-Inhibitor IC85=18 ug/ml JNP59:643 ; Protisticide CE7:285 ; Quinone-Reductase-Inducer 5 ug/ml AR19:35 ; Sodium-Sparing 3 mg/rat IWU

References

525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
ACM:211: Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 211.
AR19:35: Lee, S. K., Song, Y., Mata-Greenwood, E., Kelloff, G. J., Steele, V. E., Pezzuto, J. M. 1999. Modulation of in vitro Biomarkers of the Carcinogenic Process by Chemopreventive Agents. Anticancer Res., 19: 35-44.
BCI28:735: Balanehru, S. and Nagarajan, B. 1992. Intervention of Adriamycin Induced Free Radical Damage. Biochemistry International 28(4): 735-744, 1992.
BO2: Jim Duke's personal files
CAB: Fernando Cabieses, 1994.
CAN: Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
CCO: Chemical Constituents of Oriental Herbs (3 diff. books)
CE7:285: Chemical Express, 7: 285, 1992.
CLE104:43: Jim Duke's personal files
CPB38:1702: Jim Duke's personal files
CPB39:3276: Tsuruga, T., Chun, Y.-T., Ebizuka, Y., and Sankawa, U. 1991. Biologically Active Constituents of Melaleuca leucadendron: Inhibitors of Induced Histamine Release from Rat Mast Cells. Chem. Pharm. Bull. 39(12): 3276-3278, 1991.
CR54:701: Cancer Research, 54: 701, 1994.
DFN:159: Jim Duke's personal files
DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.
FIT68:387: Jim Duke's personal files
FT63(3):195: Jim Duke's personal files
FT66(4):369: Jim Duke's personal files
HH2: Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.
IJO16:4: Internat. J. Oriental Med. 16: 4.
IWU: Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.
JAD: Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705.
JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
JE27:243: Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989.
JE36:219: Jim Duke's personal files
JE49:57: Jim Duke's personal files
JNP41:503: Jim Duke's personal files
JNP53(3):513: Jim Duke's personal files
JNP54:453: Jim Duke's personal files
JNP54:455: Aquino, R., De Feo, V., De Simone, F., Pizza, C.*, and Cirino, G. Plant Metabolites. New Compounds And Anti-Inflammatory Activity Of Uncaria tomentosa. Journal of Natural Products, 54(2): 453-459, 1991.
JNP59:643: Jim Duke's personal files
JNP59:987: Jim Duke's personal files
JNP61:1090: Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
JNP61:1212: Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215.
LAF: Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
LAF351: Jim Duke's personal files
LS50:491: Jim Duke's personal files
M18481: Jim Duke's personal files
PAT.4,844,901: Jim Duke's personal files
PC30:1635: Jim Duke's personal files
PJB1(1):181: Jim Duke's personal files
PM56(2):173: Jim Duke's personal files
PM57:A56: Planta Medica, 57: A56, 1991.
PM59:A583: Jim Duke's personal files
PMP24:113: Jim Duke's personal files
PMP24:116: Jim Duke's personal files
POP:113: Jim Duke's personal files
PPB17:990: Jim Duke's personal files.
PR13:115: Jim Duke's personal files
PR6:74: Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992.
RT.PAT.4,844,901: Jim Duke's personal files
WOI: ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.
ppm = parts per million
tr = trace

Phytochemical Database, USDA - ARS - NGRL, Beltsville Agricultural Research Center, Beltsville, Maryland
Thu May 16 16:04:45 EDT 2002

Please send questions and comments to:

James A. Duke (E-Mail: JimDuke@cpcug.org)
or
Stephen M. Beckstrom-Sternberg (E-Mail: SteveBS@nhgri.nih.gov)

Please send technical questions and comments to:

WebMaster (E-Mail: WebMaster@ars-grin.gov)

The USDA does not recommend self diagnosis or self medication. Please see the disclaimer for more information.